UJI AKTIVITAS JAMU GENDONG KUDU LAOS (Morinda citrifolia L.; Alpinia galanga L.) SEBAGAI ANTIDIABETES PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN

Abstract

Kudu laos traditional drink is a mixture of Morinda citrifolia L. fruit
extract and Alpinia galanga L. rhizome. Both of the plants are known have
antidiabetic activity from in vivo data. The purpose of this study is to determine
the antidiabetic effect of kudu laos traditional drink in lowering blood glucose
levels and percent of the area damage islet of langerhans. Twenty five male wistar
rat are divided into five groups: normal group (no treatment), streptozotocin group
induced by streptozotocin dose 7 mg/200gBB, glibenklamid group induced by
streptozotocin dose 7 mg/200gBB and treated with glibenklamid suspension dose
0,27 mg/200gBB, doses group 1  and doses group 2 induced by streptozotocin
dose 7 mg/200gBB and treated with kudu laos traditional drink dose 1,9
ml/200gBB and 3,8 ml/200gBB. All of the treatment last 28 days. After 28 days
of treatment with kudu laos traditional drink dose 1,9 ml/200gBB and 3,8
ml/200gBB there is a decrease in blood glucose levels respectively 103,2 mg/dl
and 117,8 mg/dl and percent of the area demage islet of langerhans each of
4,114% and 4,263%  that are significantly different (P>0,05) with streptozotocin
group. The conculsion is jamu gendong kudu laos has the antidiabetic activities
with effective dose 1,9 ml/200gBB.

Keywords: Diabetic, Streptozotocin, Kudu laos traditional drink, Blood glucose

levels, Damage islet of langerhans