HYPOGLYCEMIC EFFECT TEST OF SWEET POTATO (Ipomoea batatas) LEAVES ETHANOL EXTRACT AGAINTS BLOOD GLUCOSE LEVEL OF ALLOXAN-INDUCED WHITE MALE WISTAR RAT (Rattus norvegicus)

Abstract

Background: Hot water infusion of sweet potato (Ipomoea batatas) leaves
empirically used as oral antidiabetic. Sweet potato leaves contain many
pholyphenol compound which can reduce blood glucose level. Objective:
This study investigated the hypoglycemic effect and effective dose of
sweet potato leaves ethanol extract compared to metformin in alloxaninduced

male Wistar rat. Method: The study was an in vivo experimental.
Thirty male Wistar rats was randomly divided into 5 experimental groups
those were negative control (CMC 0,5%), positive control (metformin),
dose 1 (1,4 g/kgBW extract), dose 2 (2,8 g/kgBW extract), and dose 3 (5,6
g/kgBW extract). The rats were induced by alloxan and the treatment each
group was given for 7 days. The resulting data is analyzed with One-way
Anova test then continued with LSD Post Hoc test. Result: Based on the
phytochemical screening, sweet potato leaves ethanol extract contain
flavonoid and tannin. Statistical analysis showed significant difference
between average of fasting blood glucose level from control group
(negative and positive) with dose 1 group (p<0,05) in post test fasting
blood glucose measurement. Effective dose of sweet potato leaves extract
was 700 mg/200 gBW. Conclusion: Ethanol extract of sweet potato
leaves was suspected had blood glucose reduction effect in alloxaninduced

male Wistar rat with effective dose at 700 mg/200 gBW which
showed better effect than metformin.

Key words: Ipomoea batatas, sweet potato leaves ethanol extract, alloxan
induction, phytochemical screening, blood glucose reduction.