EFFECTS OF NATURAL EXTRACT OF CELERY LEAVES ON THE KIDNEYS OF WHITE RATS (Rattus novergicus) AFTER ASPIRIN INDUCTION

Edni Indriana, Titrawani Titrawani

Abstract


Herbal plants can be used as a treatment option, including the treatment of kidney disease. The administration of herbal remedies such as celery is a more natural and safe treatment healing alternative. The study aims to determine the effect of celery extract in repairing the damage to the kidney cells of aspirin-induced white mice. This study used a completely randomized design (CRD) consisting of 5 groups with 3 replications: K- (aspirin 12.6 mg/kg BW), K+ (feed normal), P1 (celery extract 200 mg/kg BW + aspirin 12.6 mg/kg BW), P2 (celery extract 100mg/kg BW + aspirin 12.6 mg/kg BW) and P3 (celery extract 50 mg/kg BW) + aspirin 12.6 mg/kg BW). From the results of observations on kidney histology of rats after giving aspirin, it is known that there is damage to the nucleus of cells undergoing pyknosis and swelling of the glomerulus, which is characterized by narrowing of the Bowman's space. This suggests that the celery extract at a stratified dose may affect the histopathological kidney of aspirin-induced mice. 


Keywords


Aspirin; Celery (Apium graveolens L Sylvester); Kidney

Full Text:

PDF

References


Assiam, N. Setyawaty, I, & Sudirga, S.K. (2014). Pengaruh Dosis dan Lama Perlakuan Ekstrak Daun Kaliandra Merah (Calliandra calothyrsus meissn.) terhadap Struktur Histologi Ginjal Mencit (Mus musculus l). Jurnal Simbiosis. 2: 236-246

Baldatina, A.Z. (2008). Pengaruh Pemberian Insectisida (esbiothrin, imiprothrin dan d-phenothrin) pada tikus putih (Rattus rattus), Kajian Histologi Hati Dan Ginjal. Institute Pertanian Bogor. Bogor

Bjarnason, I. Scarpignato, C. Holmgren, E. Olszewski, M. Rainsford, KD, & Lanas, A. (2018). Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology, 154(3):500

Cahill, K.N & Boyce, J.A. (2017). Aspirin-exacerbated Respiratory Disease: Mediators and Mechanisms of a Clinical Diease. J. Allergy Clin Immunol. 139(3):764.

Fitmawati, Saputra, A. Kholifah, S.N. Resida, E. Roza, R.M, & Emrizal. (2020). Morphological and Histological Study of White Rats (Rattus norvegicus) Kidney Following the Consumption of Sumatran Wild Mango Extract (Mangifera spp.). Advances in Biological Sciences Research, volume 14 (261-267).

Kennedy, J.L. Stoner, A.N & Borish, L. (2016). Aspirin-exacerbated Respiratory Disease: Prevalence, Diagnosis, Treatment, and Considerations for the Future. Am, J Rhinol Allergy. 30(6):407

Li, Y. Xia, W. Zhao, F. Wen, Z. Zhang, A & Huang, S. (2018). Prostaglandins in the Pathogenesis of Kidney Diseases. Oncotarget. 9(41):26586-26602.

Mattjik. A.A & Sumetajaya, I.M. (2002). Perancangan Percobaan dengan Aplikasi SAS dan Minitab Jilid I. Bogor: IPB Press

Mayori, R. Marussin, N. & Tjong, D.H. (2013). Pengaruh Pemberian Rhodamin B terhadap Struktur Histologi Ginjal Mencit Putih (Mus musculus L.). Jurnal Biologi Universitas Andalas. 2(1): 43-49.

Pradhan, S.N. Maickel, R.P & Dutta, S.N. (1993). Pharmacology in Medicine: Principles and Practice. USA: SP Press International Inc: 224.

Sanchez, O. Arnau, A. Pareje, M. Poch, E. Ramirez,I. & Soley M. (2002). Acute Stress Induced Tissue Injury in Mice; Different Between Emotional And Social Stress. Cell Stress Society International. 50(3): 182–119.

Schreuder, M.F. Bueters, R.R. Huigen M.C. Russel, F.G.M, Masereeuw R & van-den Heuvel L.P. (2011). Effect of Drugs on Renal Development. Clinical Journal of the American Society of Nephrology 6(1) 212–217.

Segal, R. Lubart, E. Leibovitz, A. Iaina, A & Caspi D. (2006). Renal Effects of Low Dose Aspirin in Elderly Patients. Isr Med Assoc J. 8:679-682

Septiana, S & Kurniati, R. (2009). Pengaruh Pendedahan Ekstrak Batang Tabar Kedayan (Aristolochia papillfolia Ding Hou) terhadap Struktur Jaringan Ginjal Mencit (Mus musculus L). Bioprospek. 6: 16-22

Silisia, Y.H. Febrianti, N. & Dhaniaputri, R. 2016. Efek Protektif Jus Buah Tomat Merah (Lycopersicum esculentum) dan Tomat Ungu (Lycopersicum esculentum var. Indigo rose) terhadap Gambaran Histopatologik Ginjal Mencit Jantan (Mus musculus) yang Diinduksi Aspirin. Prosiding Symbion (Symposium on Biology Education). 483-490.

Suhita, N.L.P.R. Sudira, I.W. & Winaya, I.B.O. (2013). Histopatologi Ginjal Tikus Putih akibat Pemberian Ekstrak Pegagan (Centella asiatica) per Oral. Buletin Veteriner Udayana. 5(2):71-78

Sulistyowati, Y. Setyobroto, I. Anggiana, R & Pratiwi R. (2013). Pengaruh Pemberian Ekstrak Air Herba Ciplukan (Physalis angulata L.) Terhadap Histologi Ginjal Tikus Galur Sprague Dawley Hiperglikemia. Di dalam: Prosiding Seminar Nasional 2013 Menuju Masyarakat Madani Dan Lestari Halaman 461-468.

Susilo, A & Ismail, A. (2014). Pengaruh Pemberian Metanil Yellow PeroRAL Dosisi bertingkat selama 30 Hari terhadap Gambaran Histopatologi Ginjal Mencit Balb/c. Jurnal Kedokteran Diponegoro. 3(1):1-16.

Wilson, L.M. (2006) Pengobatan Gagal Ginjal Kronik. Dalam: Hartanto H, Susi N, Wulansari P, Mahanani DA, editor. Patofisiologi Konsep Klinis Proses -Proses Penyakit. 6 ed. Vol 2. Jakarta: EGC. Hal: 965-978.

Yulian, M. (2014). Potensi Biodiversitas Indonesia Sebagai Inhibitor Xantina Oksidase Dan Antigout. Lantanida Journal. 1(1): 1-15.

Yunita, E.P. Hidayanti, P.A.N, & Tjahjono C.T. (2020). Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner. Jurnal Manajemen dan Pelayanan Farmasi. 10 (3): 186-194




DOI: http://dx.doi.org/10.26418/jpmipa.v13i2.54598

Refbacks

  • There are currently no refbacks.


Abstracted/Indexed by:

S3    


PUBLISHED BY:

Fakultas Keguruan dan Ilmu Pendidikan Universitas Tanjungpura

Creative Commons License
Jurnal Pendidikan Matematika dan IPA is licensed under a Creative Commons Attribution 4.0 International License

View My Stats