Muhamad Rokim


3′,4′-dimethoxy flavonol have been synthesized from 3,4-dimethoxy-2’-hydroxychalcon under basic condition (KOH). The structures of all compounds were characterized based on the interpretation of HPLC chromatorgrams and spectroscopic data including UV, FTIR, NMR and HRMS. Antioxidant activity was evaluated using the DPPH assay and anticancer activity was evaluated using the MTS assay which showed that the 3′,4′-dimethoxy flavonol was active as antioxidants and weak anticancer activity.

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Dias, T.A., Duarte, C.L., Lima, C.F., Proenca, M.F. & Pereira-Wilson, C. 2013. Superior Anticancer Activity of Halogenated Chalcones and Flavonols Over the Natural Flavonol Quercetin. European Journal of Medicinal Chemistry, 65: 500-510.

Burmistrova, O., Marrero, M.T., Estevez, S., Welsch, I., Brouard, I., Quintana, J. & Estevez, F. 2014. Synthesis and Effects on Cell Viability of Flavonols and 3-Methyl Ether Derivatives on Human Leukemia Cells. European Journal of Medicinal Chemistry, 84: 30-41.

Britton, R.G., Horner-Glister, E., Pomenya, O.A., Smith, E.E., Denton, R., Jenkins, P.R., Steward, W.P., Brown, K., Gescher, A. & Sale, S. 2012. Synthesis and Biological Evaluation of Novel Flavonols as Potential Anti-Prostate Cancer Agent. European Journal of Medicinal Chemistry, 54: 952-958.

Jadhav, S.B., Bagul, K.R., Bagul, P.R. & Gaikwad, K.V. 2008. Synthesis of Some Novel Flavonol Derivatives and Its Antimicrobial Activity. Oriental Journal of Chemistry, 24(2): 583-588.

Zhang, Q., Zhang, J., Shen, J., Silva, A., Dennis, D.A. & Barrow, C.J. 2006. A Simple 96-Well Microplate Method for Estimation of Total Polyphenol Content in Seaweeds. Journal of Applied Phycology, 18: 445-450.

Bennett, M., Burke, J.A. & O’Sullivan, W.I. 1996. Aspects of the Algar-Flynn-Oyamada (AFO) Reaction. Tetrahedron, 52(20): 7163-7178.

Gormley, T.R. & O’Sullivan W.I. 1973. Flavanoid Epoxides-XIII1 Acid and Base Catalysed Reactions of 2’-toxyloxychalcone epoxides. Mechanism of the Algar-Flynn-Oyamada Reaction. Tetrahedron, 29(2): 369-373.

Molyneux, P. 2004. The Use of The Stable Free Radical Diphenyl picrylhydrazyl (DPPH) for Estimating Antioxidant Activity. Journals Songklanakarin Science Technology, 26: 212-219.

Riss, T.L., R.A. Moravec, A.L. Niles, H.A. Benink, T.J. Worzella, & L.Minor. 2004. Cell viability assays. Assay Guidance Manual : 1-23.

Huang, K.T., Y.H. Chen, and A.M. Walker. 2004. Inaccuracies in MTS assays: major distorting effects of medium, serum albumin, and fatty acids. BioTechniques 37: 406-412



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Indonesian Journal of Pure and Applied Chemistry (IJoPAC)

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