UJI AKTIVITAS GEL TABIR SURYA EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DENGAN VARIASI GELLING AGENT CARBOPOL 940 SECARA IN VITRO

Hikmah Dwi Rahmawati, Endang Sri Rejeki, Anita Nilawati

Abstract


Excessive sun exposure is dangerous for humans because it has many detrimental effects on the eyes, immune system as well as on the skin. Sunscreen can prevent the harmful effects of UV radiation and free radicals. Flavonoid compounds in mangosteen rind have natural sunscreen activity. The purpose of this study was to determine the physical quality and stability and activity of the ethanol extract gel of mangosteen peel in vitro with variations of carbopol 940. The extract was obtained from the maceration process using 70% ethanol. The gel was formulated using 0.1% extract and 0.5% gelling agent variations; 1%; and 1.5%. Gel test parameters including organoleptic test, homogeneity, viscosity, pH, spreadability, adhesion stability test cycling test, and sunscreen gel activity test were carried out in vitro by measuring the value of Sun Protection Factor (SPF) using UV spectrophotometry. The results showed that the 0.1% mangosteen rind ethanol extract gel formulation with variations of the gelling agent carbopol 940 0.5;1 and 1.5% had good physical quality and stability as well as sunscreen activity with an SPF value of 41,099; 39,898; 39,270 with the ultra category.


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References


Ansel, H.C., Popovich, N.G., Allen, L.V. (2011). Pharmaceutical Dosage Form and Drug delivery System Ninth Edition.

London: New York.

Ansori, A. N. M., Fadholly, A., Hayaza, S., Susilo, R. J. K., Inayatillah, B., Winarni, D., & Husen, S. A. (2020). A review on

medicinal properties of mangosteen (Garcinia mangostana L.). Research Journal of Pharmacy and Technology,

(2), 974–982. https://doi.org/10.5958/0974-360X.2020.00182.1

Budiman, A., Aulifa, D. L., Kusuma, A. S. W., Kurniawan, I. S., & Sulastri, A. (2017). Peel-off gel formulation from black

mulberries (Morus nigra) extract as anti-acne mask. National Journal of Physiology, Pharmacy and Pharmacology,

(9), 987–994. https://doi.org/10.5455/njppp.2017.7.0413123052017

Fahrezi, M. A., Nopiyanti, V., & Priyanto, W. (2021). Formulasi dan Uji Aktivitas Tabir Surya Gel Kitosan Menggunakan

Karbopol 940 dan HPMC K100 sebagai Gelling Agent. Jurnal Farmasi (Journal of Pharmacy), 10(1), 17–23.

https://doi.org/10.37013/jf.v10i1.116

Forestryana, D., Surur Fahmi, M., & Novyra Putri, A. (2020). Pengaruh Jenis dan Konsentrasi Gelling Agent pada

Karakteristik Formula Gel Antiseptik Ekstrak Etanol 70% Kulit Buah Pisang Ambon. Lumbung Farmasi: Jurnal Ilmu

Kefarmasian, 1(2), 45. https://doi.org/10.31764/lf.v1i2.2303

Guan, L. L., Lim, H. W., & Mohammad, T. F. (2021). Sunscreens and Photoaging: A Review of Current Literature.

American Journal of Clinical Dermatology, 22(6), 819–828. https://doi.org/10.1007/s40257-021-00632-5

Gunarti, N. S., & Fikayuniar, L. (2020). Formulasi dan Uji Aktivitas Gel Tabir Surya dari Ekstrak Buah Blackberry (Rubus

fruticosus) Secara In Vitro dengan Spektrofotometri UV-Visibel. Kartika : Jurnal Ilmiah Farmasi, 7(2), 66–72.

https://doi.org/10.26874/kjif.v7i2.227

Iryani, Y. D., Astuti, I. Y., & Diniatik, D. (2021). Optimasi Formula Sediaan Losion Tabir Surya dari Ekstrak Etanol

Terpurifikasi Kulit Buah Manggis (Garcinia mangostana L) Dengan Metode Simplex Lattice Design. Jurnal Sains

Farmasi & Klinis, 8(2), 145. https://doi.org/10.25077/jsfk.8.2.145-156.2021

Kementerian Kesehatan Republik Indonesia. (2013). Farmakope Herbal Indonesia. Edisi I. Jakarta: Kementerian

Kesehatan Republik Indonesia.

Kementerian Kesehatan Republik Indonesia. (2017). Farmakope Herbal Indonesia. Edisi II. Jakarta: Kementerian

Kesehatan Republik Indonesia.

Keshavarzi, F., Knudsen, N. Ø., Komjani, N. M., Ebbesen, M. F., Brewer, J. R., Jafarzadeh, S., & Thormann, E. (2022).

Enhancing the sweat resistance of sunscreens. Skin Research and Technology, 28(2), 225–235.

https://doi.org/10.1111/srt.13115

Mursal, I.L.P., Kusumawati, .H., & Puspasari, D.H. (2019). Pengaruh Variasi Konsentrasi Gelling Agent Carbopol 940

Terhadap Sifat Fisik Sediaan Gel Hand Sanitizer Minyak Atsiri Daun Kemangi (Ocium Sanctum L.). Pharma Xplore :

Jurnal Ilmiah Farmasi, 4(1), 268–277. https://doi.org/10.36805/farmasi.v4i1.617

Puspitasari, A. D., & Kusuma Wardhani, E. I. (2018). Evaluasi Karakteristik Fisika-Kimia dan Nilai SPF Lotion Tabir Surya

Ekstrak Daun Kersen (Muntingia calabura L.). Jurnal Riset Teknologi Industri, 12(2), 150–158.

https://doi.org/10.26578/jrti.v12i2.4242

Rizaldy, D., Hartati, R., Nadhifa, T., & Fidrianny, I. (2022). Chemical compounds and pharmacological activities of

mangosteen (Garcinia mangostana l.)-updated review. Biointerface Research in Applied Chemistry, 12(2), 2503–

https://doi.org/10.33263/BRIAC122.25032516

Rompis, F., Yamlean, P. V., dan Lolo, W. A. (2019). Formulasi dan Uji Efektivitas Antioksidan Sediaan Masker Peel-Off

Ekstrak Etanol Daun Sesewanua (Cleodendron squamatum Vahl.). PHARMACON, 8(2), 388-396.

https://doi.org/10.35799/pha.8.2019.29305

Safitri, F. I., Nawangsari, D., & Febrina, D. (2021). Overview: Application of Carbopol 940 in Gel. 34 (Ahms 2020), 80–84.

https://doi.org/10.2991/ahsr.k.210127.018

Sulistyarini, I., Sari, D. A., dan Wicaksono, T. A. (2020). Skrining Fitokimia Senyawa Metabolit Sekunder Batang Buah

Naga (Hylocereus polyrhizus). Cendekia Eksakta, 5(1).

https://garuda.kemdikbud.go.id/documents/detail/1662514 diakses tanggal 2 November 2022

Tsabitah, A. F., Zulkarnain, A. K., Wahyuningsih, M. S. H., & Nugrahaningsih, D. A. A. (2020). Optimasi Carbomer,

Propilen Glikol, dan Trietanolamin Dalam Formulasi Sediaan Gel Ekstrak Etanol Daun Kembang Bulan (Tithonia

diversifolia). Majalah Farmaseutik, 16(2), 111–118. https://doi.org/10.22146/farmaseutik.v16i2.45666

Utami, S.M. (2019). Pengaruh Basis Carbopol Terhadap Formulasi Sediaan Gel Dari Ekstrak Daun Katuk (Sauropus

androgynus (L.) Merr). Edu Masda Journal, 3(1).

http://openjournal.masda.ac.id/index.php/edumasda/article/view/22 diakses tanggal 10 November 2022

Yeager, D.G., Lim, H.W. (2019). What's New in Photoprotection: A Review of New Concepts and Controversies.

Dermatologic clinics, 37(2), pp. 149-157. https://doi.org/10.1016/j.det.2018.11.003




DOI: https://doi.org/10.26418/edunaturalia.v4i1.61787

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