UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN KRIM TIPE M/A DARI MINYAK ATSIRI KULIT BUAH JERUK PONTIANAK (Citrus nobilis Lour. var. microcarpa) TERHADAP ISOLAT Propionibacterium acnes SECARA IN VITRO

Neny Lucyani .

Abstract


Acne is a skin disorder which is caused by the Propionibacterium acnes bacteria. One of the
substances that can be benefitted as an antibacterial product is Pontianak citrus (Citrus nobilis
Lour. Var. Microcarpa) peel essential oil. Essential oil is obtained through the process of
steam distillation. This study aims to determine the effect of formulated antibacterial cream
of essential oil of Pontianak citrus’ peel to P. acnes isolates by disc diffusion method (KirbyBauer
test).
Essential
oils
formulated
in
dosage
forms
cream
with
essential
oil
concentration

ratio

F1 (0.025%), F2 (0.05%) and F3 (0,1%). Evaluation of organoleptic examinations of
such preparations include odor, color, shape and homogeneity, dispersive power testing,
adhesion, pH and antibacterial. Data analysis is done by using the R-Commander program
version 2.14.1. The results showed that the inhibitory zone in F1, F2 and F3 is 18mm, 20mm
and 21,67mm. The evaluation results indicate a homogeneous preparation, pH is in
accordance to the peel’s pH and there is a decrease of adhesion and increase of dispersive
power. The results of antibacterial cream evaluation showed that formula 1 gives the best
effectiveness with inhibition zone of 18 mm to the P. acnes isolates.

Keyword: Acne, Pontianak citrus peel essential oil, P. acnes


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